Non-Inferiority and Equivalence Sample Size

Compute sample size for non-inferiority trials, equivalence (TOST), cluster-randomized studies (design effect) and diagnostic accuracy studies. With dropout adjustment.

How to cite this tool

If you use it in your thesis or in a paper, cite it so that readers of your Methods section know how the calculation was done.

Ciudad-Fernández, V. (2026). Clinical study sample size calculator [Web application]. Ciudad Science. Retrieved October 14, 2026, from https://analisisdedatospsicologia.com/en/tools/clinical-sample-size-calculator

For your Methods section: Sample size was computed with the Ciudad Science clinical study sample size calculator (Ciudad-Fernández, 2026), which, depending on the design, applies among others the formulas of Julious (2004) for continuous outcomes, Schuirmann (1987) for equivalence trials and Buderer (1996) for diagnostic accuracy studies.

@misc{ciudadfernandez2026tamanomuestralclinico,
  author       = {Ciudad-Fern{\'a}ndez, V{\'i}ctor},
  title        = {{Clinical study sample size calculator}},
  year         = {2026},
  publisher    = {Ciudad Science},
  howpublished = {Web application},
  url          = {https://analisisdedatospsicologia.com/en/tools/clinical-sample-size-calculator},
  urldate      = {2026-10-14},
  note         = {Accessed 2026-10-14},
}

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